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Photomutagenic properties of chlorinated phenothiazine derivatives are attributed to induction of UV-A radiation dechlorination followed by formation of the promazyl radical which binds covalently to the DNA molecule (Gocke 1996)

Data were available for aspartame for the following key characteristics of carcinogens: is electrophilic or can be metabolized to an electrophile, is genotoxic, induces oxidative stress, induces chronic inflammation, is immunosuppressive, modulates receptor-mediated effects, causes immortalization, and alters cell proliferation, cell death, or nutrient supply

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Mechanistically, organophosphate hydrolases (OPH/phosphotriesterases) catalyze hydrolysis of PO/PS/PF bonds in organophosphates